„Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers“

Find here our newest work on translational mouse models for targeting YAP/TAZ in advanced cancers. Here, Marco performed proof-of-concept studies demonstrating the feasibility of targeting YAP/TAZ in advanded cancers and provide mechanistic insights into their oncogenic activities.

„A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth“

In this study, we identify a tumor-suppressive role of the JUN transcription factor to restrain oncogenic YAP activity in liver cancer.

„TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity“

In this study, we identify a role for the transcription factor TRPS1 in maintaining the luminal progenitor (LP) population of the mammary gland. This study provides insight into the differentiation trajectories of LPs which are the cell-of-origin for numerous breast cancer types.

„Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity“

Here, we can demonstrate that TAZ is potently induced in aging hematopoietic stem cells (HSCs) and that it protects HSCs from aging-associated decline by buffering the activity of the PU.1 transcription factor.